陈琳医生

陈琳，女，主治医师。教育经历：2016/10-2016/12，美国内布拉斯加大学医学中心，访问学者；2008/09-2011/06，海军军医大学，肿瘤研究所，硕士，导师：郭亚军；2001/09-2006/06，南昌大学医学院，临床一系，学士，导师：周婷。主持课题及人才培养计划：1.同济大学基础研究能力提升计划（中央高校基本科研业务费专项资金），2017/09-2018/06，5万，在研，主持；2.上海市卫计委青年项目，20164Y0272，《IGF-1R相关PPAR信号通路表达异常引起直肠癌放疗抵抗作用机制研究》，2017/01-2019/12，2万，在研，主持；3.浦东新区卫计委青年项目，PW2016B-4，《益比奥（重组人红细胞生成素注射液）联合蔗糖铁与其单药比较治疗常规剂量低反应的化疗相关性贫血患者临床研究》，2017/01-2019/11，3万，在研，主持；4.上海青年医师培养资助计划（沪卫计人事[2015]147号），2016/01-2018/12，10万，资助中，主持。代表性研究成果：（1）Lin Chen#, Zhe Zhu#, Wei Gao, Qixin Jiang, Jiangming Yu, Chuangang Fu* Systemic analysis of different colorectal cancer cell lines and TCGA datasets identified IGF-1R/EGFR-PPAR-CASPASE axis as important indicator for radiotherapy sensitivity. Gene, 627（2017）484-490（2）Lin Chen#, Hong Jiang,# Wei Gao,# Ye Tu, Ying Zhou, Xi Li, Zhe Zhu, Qixin Jiang, Haifeng Zhan, Jiangming Yu, Chuangang Fu, Yong Gao* Combination with intravenous iron supplementation or doubling erythropoietin dose for patients with chemotherapy-induced anaemia inadequately responsive to initial erythropoietin treatment alone: study protocol for a randomised controlled trial. BMJ Open, 2016;6:e012231.doi:10.1136（3）Lin Chen#, Feng Chen,# Mengxin Zhao,# Xiandi Zhu,# Changhong Ke,# Jiangming Yu, Zhiqiang Yan, Fulei Zhang, Yun Sun, Di Chen, Cheng Jiang, Xianxian Zhao, Yong Gao,* Shangjing Guo,* Wei Li* A redox-sensitive micelle-like nanoparticle self-assembled from amphiphilic adriamycin-human serum albumin conjugates for tumor targeted therapy. BioMed Research International, Volume 2015, 2015: 987404（4）Chen Y#, Chen L,# Lu Q, Meng Y, Wang L, Wang H, Yu X, Zhang Y, Zhao L, Li B, Guo Y* Optimization of anti-CD20 humanized antibody hu8E4 by site-directed mutation based on epitope analysis. Biochemical and Biophysical Research Communications, 2015, 459(4):617-622（5）Kou G#, Shi J#, Chen L,# Zhang D, Hou S, Zhao L, Fang C, Zheng L, Zhang X, Liang P, Zhang X, Li B, Guo Y* A bispecific antibody effectively inhibits tumor growth and metastasis by simultaneous blocking vascular endothelial growth factor A and osteopontin. Cancer Letters, 2010, 299(2):130-136.