殷晓煜医生

一、研究方向： 1、胰腺恶性肿瘤、神经内分泌肿瘤的临床与基础研究； 2、胆道恶性肿瘤临床与基础研究； 3、肝脏恶性肿瘤临床与基础研究； 至今已主持5项国家自然科学基金、近10项省部级基金资助的课题研究，取得了丰硕的成果。 三、社会兼职： 1、中华医学会外科学分会第十八届委员会胰腺外科学组委员； 2、中国抗癌协会神经内分泌肿瘤专业委员会副主任委员； 3、中国抗癌协会胆道肿瘤专业委员会第四届委员会常委； 4、中国医师协会胰腺病学专业委员会第二届委员会常务委员； 5、中国医师协会外科医师分会机器人外科专家工作组副组长； 6、中国医药教育协会医疗机器人发展促进分会副主任委员； 7、中国研究型医院学会胰腺病学委员会常委； 8、中国研究型医院学会术后快速康复专业委员会常委； 9、中国研究型医院学会智能医学专业委员会常委； 10、国际肝胆胰协会中国分会胆道肿瘤专业委员会副主任委员 11、广东省医学会外科学分会副主任委员 12、广东省医学会肝胆胰外科学分会常务委员； 13、广东省医师协会胰腺病学专业委员会副主任委员； 14、广东省医疗行业协会肝胆胰外科管理分会主任委员； 15、广东省临床医学学会肝胆胰外科专业委员会主任委员； 16、广东省抗癌协会胰腺癌专业委员会副主任委员； 17、广东省抗癌协会胆道肿瘤专业委员会主任委员； 18、GastroenterologyReport》、《中华肝胆外科杂志》、《中华消化外科杂志》、《中华胰腺病学杂志》、《中华普通外科文献杂志》电子版等多家杂志编委。 四、发表论文： 目前已在“AdvancedScience(IF=14.3)”、“ACSNano(IF=15.3)”、“CancerCommunications(IF=20.1)”、“CellDeathandDifferentiation(IF=13.7)”、“MolecularTherapy(IF=12.1)”、“CancerLetters(IF=9.1”、“Oncogene(IF=6.9)”、“IntJBiolSci(IF=8.2)”、“ClinTransMed(IF=7.9)”、“AppliedMaterialsToday(IF=7.2)”、“BrJSurg(IF=8.6)”等SCI杂志、及“中华外科杂志”、”中华消化外科杂志”、“中华肝胆外科杂志”、“中国实用外科杂志”等国内核心期刊发表第一作者和（或）通讯作者论文140多篇。近期发表的部分论文如下： ShiYH,LiuZD,MaMJ,ZhaoGY,ZhuYQ,WangJQ,YuYY,HuangXT,YeJY,LiFX,WangXY,XuQC,YinXY.Platelet-DerivedGrowthFactorCFacilitatesMalignantBehaviorofPancreaticDuctalAdenocarcinomabyRegulatingSREBP1MediatedLipidMetabolism.AdvSci(Weinh).2024Sep3:e2407069.doi:10.1002/advs.202407069.Epubaheadofprint.PMID:39225567.（通讯作者）ZhuYQ,HuangY,ShiYH,HuangCS,ZhaoGY,LiuZD,MaMJ,YeJY,XuX,LiuQ,HuangXT,WangJQ,XuQC,YinXY.EpigeneticActivationoftheCMTM6-IGF2BP1-EP300PositiveFeedbackLoopDrivesGemcitabineResistanceinPancreaticDuctalAdenocarcinoma.AdvSci(Weinh).2024Nov3:e2406714.doi:10.1002/advs.202406714.Epubaheadofprint.PMID:39488785.（通讯作者）MaMJ,ShiYH,LiuZD,ZhuYQ,ZhaoGY,YeJY,LiFX,HuangXT,WangXY,WangJQ,XuQC,YinXY.N6-methyladenosinemodifiedTGFB2triggerslipidmetabolismreprogrammingtoconferpancreaticductaladenocarcinomagemcitabineresistance.Oncogene.2024Jun24.（通讯作者）LiuZD,ShiYH,XuQC,ZhaoGY,ZhuYQ,LiFX,MaMJ,YeJY,HuangXT,WangXY,XuX,WangJQ,ZhaoW,YinXY.CSNK2A1confersgemcitabineresistancetopancreaticductaladenocarcinomaviainducingautophagy.CancerLett.2024Mar31;585:216640.doi:10.1016/j.canlet.2024.216640.Epub2024Jan28.PMID:38290659.（通讯作者）HuangXT,QuXF,ZhouJW,CaiJP,XieJZ,ChenW,ChenLH,YinXY.Robotic-assistedorgan-preservingorparenchymal-sparingpancreatectomyinpancreaticbenignorlow-grademalignanttumors:asingleinstitute’sexperience.JRoboticSurgery.2024:18:1.（通讯作者）WangXY,HuangXT,CaiJP,LiB,ChenW,HuangCS,YinXY.Robotic-AssistedVersusOpenHemi-Hepatectomy:APropensityScoreAnalysis.JSurgRes2024;https://doi.org/10.1016/j.jss.2024.09.001。（通讯作者）WuX,LiJH,XuL,LiYX,ZhuXX,WangXY,WuX,ZhaoW,NiX,YinXY.SUMOspecificpeptidase3haltspancreaticductaladenocarcinomametastasisviadeSUMOylatingDKC1.CellDeathDiffer.2023May15.doi:10.1038/s41418-023-01175-4.（通讯作者）HuangXT,XieJZ,CaiJP,ChenW,ChenLH,YinXY.Learningcurveofrobotic-assistedsplenicvessel-preservingspleen-preservingdistalpancreatectomybyonesinglesurgeon:aretrospectivecohortstudy.BMCSurgery2023;23:382.（通讯作者）HuangXT,CaiJP,YinXY.Robotic-assistedhepatopancreatoduodenectomyandresectionofpancreatictailforonemultipleendocrineneoplasiatype1secretingmultiplehormones.HepatoBiliarySurgeryandNutrition2023;doi:10.21037/hbsn-23-315.（通讯作者）HuangXT,WangXY,XieJZ,CaiJP,ChenW,ChenLH,YinXY.Learningcurvesofresectionandreconstructionproceduresinrobotic-assistedpancreatoduodenectomybyasinglesurgeon:aretrospectivecohortstudyof160consecutivecases.GastroenterolRep(Oxf).2023;11:goad042.doi:10.1093/gastro/goad042.eCollection2023.（通讯作者）YeJY,FangP,PengZP,HuangXT,XieJZ,YinXY.radiomics-basedinterpretablemodeltopredictthepathologicalgradeofpancreaticneuroendocrinetumors.EuropeanRadiology.2023;https://doi.org/10.1007/s00330-023-10186-1（通讯作者）HuangXT,XieJZ,CaiJP,ChenW,ChenLH,LiangLJ,YinXY.Evaluationoftheshort-termoutcomesofrobotic-assistedradicalresectionforperihilarcholangiocarcinoma:apropensity-scoredmatchinganalysis.GastroenterolReport2023,11,goad018.（通讯作者）ShiYH,XuQC,ZhuYQ,LiuZD,ZhaoGY,LiuQ,WangXY,WangJQ,XuX,SuQ,LaiJM,HuangCS,YinXY.ImatinibfacilitatesgemcitabinesensitivitybytargetingepigeneticallyactivatedPDGFCsignalinginpancreaticcancer.MolTher.2022Nov15:S1525-0016(22)00662-1.（通讯作者）HuangCS,XuQC,DaiC,WangL,TienYC,LiF,SuQ,HuangXT,WuJ,ZhaoW,YinXY.Nanomaterial-FacilitatedCyclin-DependentKinase7InhibitionSuppressesGallbladderCancerProgressionviaTargetingTranscriptionalAddiction.ACSNano.2021Sep28;15(9):14744-14755.（通讯作者）XuQC,TienYC,ShiYH,ChenS,ZhuYQ,HuangXT,HuangCS,ZhaoW,YinXY.METTL3promotesintrahepaticcholangiocarcinomaprogressionbyregulatingIFIT2expressioninanm6A-YTHDF2-dependentmanner.Oncogene.2022Mar;41(11):1622-1633.（通讯作者）HuangXT,LiJH,ZhuXX,HuangCS,GaoZX,XuQC,ZhaoW,YinXY.HNRNPCimpedesm6A-dependentanti-metastaticalternativesplicingeventsinpancreaticductaladenocarcinoma.CancerLett.2021Oct10;518:196-206.（通讯作者）LiYX,ZhuXX,WuX,LiJH,NiXH,LiSJ,ZhaoW,YinXY.ACLPpromotesactivationofcancer-associatedfibroblastsandtumormetastasisviaACLP-PPARγ-ACLPfeedbackloopinpancreaticcancer.CancerLett.2022Sep28;544:215802.（通讯作者）XuQC,TienYC,ShiYH,ChenSY,ZhuYQ,HuangXT,HuangCS,ZhaoW,YinXY.METTL3promotesintrahepaticcholangiocarcinomaprogressionbyregulatingIFIT2expressioninanm6A-YTHDF2-dependentmanner.Oncogene2022;doi:10.1038/s41388-022-02185-1.（通讯作者）HuangCS,ZhuYQ,XuQC,ChenSY,HuangY,ZhaoGY,NiXH,LiuB,ZhaoW,YinXY.YTHDF2promotesintrahepaticcholangiocarcinomaprogressionanddesensitizescisplatintreatmentbyincreasingCDKN1BmRNAdegradationRunningtitleYTHDF2drivesICCprogressionandchemo-resistance.Clin.Transl.Med.2022;12:e848.（通讯作者）LiYX,ZhuXX,WuX,LiJH,NiXH,LiSJ,ZhaoW,YinXY.ACLPpromotesactivationofcancer-associatedfibroblastsandtumormetastasisviaACLP-PPARγ-ACLPfeedbackloopinpancreaticcancer.CancerLetter2022.https://doi.org/10.1016/j.canlet.2022.215802.（通讯作者）NiX;WuX;ZhuXX;LiJH;YinXY;LuL.CarabinDeficiencyAggravatesHepaticIschemia-ReperfusionInjuryThroughPromotingNeutrophilTraffickingviaRasandCalcineurinSignaling.FrontImmunol.2022;13;773291.（共同通讯作者）HuangCS,XuQC,DaiCL,WangLY,TienYC,LiFX,SuQ,HuangXT,WuJ,ZhaoW,YinXY.Nanomaterial-FacilitatedCyclin-DependentKinase7InhibitionSuppressesGallbladderCancerProgressionviaTargetingTranscriptionalAddiction.ACSNano.2021;15(9):14744-14755.（通讯作者）HuangXT,CaiJP,ChenW,HuangCS,LiJH.GangTT,LiangLJ,YinXY.Establishmentandvalidationofanomogramforpredictingoverallsurvivalofnodenegativeperihilarcholangiocarcinoma.AsianJSurg.2022;45:712-717.（通讯作者）CaiJP,ChenW,ChenLH,WangXY,LaiJM,YinXY.Comparisonbetweenrobotic-assistedandlaparoscopiclefthemi-hepatectomy.AsianJSurg2022;45(1):265-268.（通讯作者）HuangXT,LiJH,ZhuXX,HuangCS,GaoZX,XuQC,ZhaoW,YinXY.HNRNPCimpedesm6A-dependentanti-metastaticalternativesplicingeventsinpancreaticductaladenocarcinoma.CancerLetter.2021;518:196–206.（通讯作者）XuQC,WangLY,TongT,HuangXT,HuangCS,LiFX,SuQ,TienYC,WuJ,ZhaoW,YinXY.EfficientDeliveryofBRD4InhibitorbyGlutathione-sensitiveNanoparticletoSuppressGallbladderCancerThroughInhibitingNF-κBSignaling.AppliedMaterialToday2020;21:100849.（通讯作者）WangXY,CaiJP,SongLL,HuangCS,ChenW,HuangXT,ChenSF,LiuXY,YinXY.IdentificationofGenomicAlterationsinSporadicPancreaticNeurogenicTumors.Pancreas2020;49:1393-1397.（通讯作者）HuangXT,HuangCS,LiuC,ChenW,CaiJP,ChengH,JiangXX,LiangLJ,YuXJ,YinXY.DevelopmentandValidationofaNewNomogramforPredictingClinicallyRelevantPostoperativePancreaticFistulaAfterPancreatoduodenectomy.WorldJSurg2021,45,261-269.（通讯作者）HuangXT,HuangCS,LiJH,ChenW,GanTT,WangXY,LiangLJ,YinXY.Evaluatingtheadequacyofnodalstatusinnode-negativegallbladdercancerwithT1b-T2stages:useofnodalstagingscore.HPB(Oxford)2021;23(5):795-801.（通讯作者）HuangCS,YouX,DaiC,XuQC,LiF,WangL,HuangXT,WangJQ,LiSJ,GaoZ,WuJ,YinXY,ZhaoW.TargetingSuper-EnhancersviaNanoparticle-FacilitatedBRD4andCDK7InhibitorsSynergisticallySuppressesPancreaticDuctalAdenocarcinoma.Adv.Sci.2020,7(7):1902926.（共同通讯作者）ChenHD,HuangCS,XuQC,LiFX,HuangXT,WangJQ,LiSJ,ZhaoW,YinXY.TherapeuticTargetingofCDK7SuppressesTumorProgressioninIntrahepaticCholangiocarcinoma.IntJBiolSci.2020;16(7):1207-1217.（通讯作者）WangJQ,WangLY,LiSJ,TongT,WangL,HuangCS,XuQC,HuangXT,LiJH,WuJ,ZhaoW,YinXY.HistonemethyltransferaseG9ainhibitor-loadedredox-responsivenanoparticlesforpancreaticductaladenocarcinomatherapy.Nanoscale.2020;12(29):15767-15774.（通讯作者）HuangXT,HuangCS,LiJH,XuQC,YinXY.Useofnodalstagingscoreinevaluatingtheaccuracyofpathologicnodalstatusinnode-negativeampullarycarcinoma.JGastrointestinalSurg.2021;25:1001-1009.（通讯作者）ZhuXX,LiJH,CaiJP,HouX,HuangCS,HuangXT,WangJQ,LiSJ,XuQC,YinXY.EYA4inhibitshepatocellularcarcinomabyrepressingMYCBPbydephosphorylatingβ-cateninatSer552.CancerSci.2019;110(10):3110-3121.（通讯作者）HuangXT,HuangCS,ChenW,CaiJP,GanTT,ZhaoY,LiuQ,LiangLJ,YinXY.Developmentandvalidationofanomogramforpredictingoverallsurvivalofnode-negativeampullarycarcinoma.JSurgOncol.2020;121(1):518–523.（通讯作者）GaoSW,HuangCS,HuangXT,ChenLH,ChenW,CaiJP,YinXY.Ki-67Indexof5%isBetterThan2%inStratifyingG1andG2ofWHOGradingSysteminPancreaticNeuroendocrineTumors.Pancreas2019;48(6):795-798.（通讯作者）HuangXT,ChenLH,HuangCS,LiJH,CaiJP,ChenW,YinXY.EstablishmentofaNomogrambyIntegratingMolecularMarkersandTumor-Node-MetastasisStagingSystemforPredictingthePrognosisofHepatocellularCarcinoma.DigSurg.2019;36(5):426-432.（通讯作者）黄锡泰谢锦钊蔡建鹏许琼聪黄晨松陈流华陈伟殷晓煜。单一术者机器人辅助胰十二指肠切除术的近期疗效分析。中华消化外科杂志，2024；23（4）:596-600.殷晓煜。胆囊管癌的临床特征及治疗。中国实用外科杂志。2023；43（11）:56-58.殷晓煜.机器人辅助肝门部胆管癌根治术的应用现状、优势及局限性.中华腔镜外科杂志（电子版）.2022;15(2):69-72.蔡建鹏，陈伟，王曦域，陈流华，殷晓煜。机器人辅助胰十二指肠切除术在高龄患者的应用。中华腔镜外科杂志。2021；14（1）：10-14.（通讯作者）陈流华，黄锡泰，陈伟，赖佳明，梁力建，殷晓煜。全尾状叶切除在肝门部胆管癌根治术中的应用。中华肝脏外科手术学杂志。2021；10（6）：559-563。（通讯作者）黄锡泰、蔡建鹏、陈伟、房鹏，陈流华，殷晓煜。机器人辅助保留脾脏远端胰腺切除术围手术期指标回顾性研究。中国实用外科杂志。2021；41（12）:1407-1422.（通讯作者）黄晨松，钟记华，陈伟，蔡建鹏，赖佳明，梁力建，殷晓煜。不同类型胰腺囊性肿瘤的诊断与治疗。中华消化外科杂志。2020；19（12）：1-7.（通讯作者） 五、专著： YinXY.Diagnosis.In:LauWY(ed).Hilarcholangiocarcinoma.SpringerScienceBusinessMediaDordrechtPeople’sMedicalPublishingHouse.2013:91-98.