吉训明医生

吉训明，长期从事脑血管病（脑卒中）防治研究，入选首届国之名医。首都医科大学宣武医院神经外科主任医师、教授、博士研究生生导师；国家杰出青年、教育部长江学者和万人计划科技领军人才；北京脑重大疾病研究院院长和首都医科大学副校长。在国家自然科学基金重大仪器研发专项、重点国际合作项目及杰出青年基金项目、科技部重点研发专项和中央军委军民融合重大项目等基金资助下，①针对疑难重症脑血栓（生命中枢脑干血栓和发病隐匿、预后凶险的难治型脑静脉血栓)，创立早期诊断新技术、首研介入治疗专用器械和治疗新方案，大幅降低卒中死亡率和致残率，改写国际指南并写入欧美教材；②针对脑血栓溶栓后不可避免的再灌注次生脑损伤难题，发现“血管内皮应激-神经元求救-线粒体转移保护-低温协同增强”的脑损伤新机制和保护新靶点，创立血管内靶向低温脑保护理论和临床新技术，解决了低温用于卒中救治的临床转化难题，被国际誉为“卒中脑保护治疗的里程碑”；③针对我国颅内动脉粥样硬化狭窄及血栓复发引起的脑损伤难于治疗的临床困境，创立长程远隔缺血适应脑保护新理论，研发专用治疗仪器，全国31个省推广应用，破解了脑保护难题，入选国际卒中领域十大进展，牵头制定中国规范和国际指南。以通讯作者在Nature、NEJM、Lancet Neurology等发表SCI论文223篇，他引16000余次，连续入选Elsevier中国高被引学者；以第一完成人获国家科技进步二等奖、中华医学科技进步一等奖和教育部科技进步一等奖，以及何梁何利科学与技术进步奖和吴阶平医学创新奖。教育经历2007.08 — 2009.08 中欧国际工商学院 EMBA2005.11 — 2006.05 哈佛大学麻省总医院高级访问学者2005.05 — 2005.10 迈阿密大学脑血管病研究所访问学 者2001.07 — 2002.01 Yasargil 显微神经外科训练班高级学员2000.10 — 2002.10 首都医科大学宣武医院神经外科博士后1998.10 — 2000.07 天津医科大学总医院博士研究生1995.09 — 1998.07 天津医科大学总医院硕士研究生1986.09 — 1991.07 南通大大学工作经历 1.199509-200007:天津医科大学 神经介入放射学 硕博士研究生2.200010-200212:首都医科大学宣武医院神经外科 博士后3.200303-200712:首都医科大学宣武医院 科研处长4.200310-200812:首都医科大学宣武医院神经外科 副主任医师 5.200510- 首都医科大学宣武医院神经病学副教授 硕士研究生导师6.200606-200705:首都医科大学宣武医院 院长助理7.200706-201910:首都医科大学宣武医院 副院长8.200708-200909:中欧国际工商学院 EMBA9. 201301-201712;国家自然科学基金委杰出青年基金 获得者10.201401-201812:教育部长江学者奖励计划 特聘教授11.201407- :低氧适应转化医学北京市重点实验室 主任12.201410-201909:人社部百千万人才国家级人选 政府特贴专家13.201512-202001:国家万人计划 中青年领军人才14.201610-202111:互联网医疗诊治技术国家工程实验室 主任15.201704- :首都医科大学心脑共病临床诊疗研究中心 主任16.201712-   :北京脑重大疾病研究院 院长17.201801- :科技部脑重大疾病防治省部共建重点实验室 主任18.201806- :北京高原适应研究康复中心 主任19.201812- :教育部脑重大疾病防治省部共建协同创新中心 主任20.201911- :首都医科大学 副校长21.202110- :北京市人才局 北京学者 22.202112- :互联网医疗诊治技术国家工程研究中心 主任学术任职1.北京神经科学学会 会长2.中国卒中学会脑静脉病变分会 会长3.中国老年医学会副会长 兼 脑血管病分会会长4.Brain Circulation 主编5.Neuroprotection 主编6.Conditioning Medicine 主编7.Journal of Translational Neuroscience 主编8.Aging and Diseases 副主编 承担课题2004.08 — 2007.10 北京市科技新星项目 血管内低温脑保护治疗急性脑缺血的实验与临床研究（2003B36） 经费38万元 主持2004.06 — 2006.11 国家十五科技攻关项目 影像指导下急性脑梗死动脉溶栓治疗研究（2004BA02B102） 经费62万元 合作主持2005.01 — 2007.12 国家自然科学基金项目 血管内低温灌注治疗急性脑缺血的实验研究(30471780) 经费25万元 主持2005.01 — 2007.12 北京市自然科学基金重大项目 缺血脑损伤的保护与修复治疗研究(7050001) 经费100万元 骨干2006.12 — 2008.12 国家863项目 急性脑梗死动脉溶栓联合区域性低温灌注研究（2006AA02Z497） 经费300万元 合作主持2006.01 — 2008.12国家自然科学基金项目 缺血/再灌注脑组织温度变化规律与干预的实验研究(30500166) 经费29万元 主持2006.10 — 2009.09 首都医学发展基金项目 急性脑缺血动脉溶栓联合脑保护治疗研究（2005-2050） 经费30万元 主持2006.12 — 2008.12 国家十一五科技支撑项目 缺血性卒中急性期病因诊断、临床分型及规范治疗（2006BAI01A11）经费600万元 骨干2009.01 — 2011.12 国家自然科学基金项目 缺血后适应对脑缺血/再灌注损伤的保护研究（30870854） 经费31万元 主持2010.01 — 2012.12 北京市卫生局骨干人才项目 远程缺血预适应脑保护治疗研究（2009-3-61） 经费 21万元 主持2010.08 — 2013.12 北京市脑血管病重大专项 缺血性脑血管病早期预警与干预研究（D111107003111008） 经费750万元 主持 2011.01 — 2013.12 北京市自然科学基金重点项目 内质网应激在缺血预适应治疗缺血性脑损伤保护中的作用研究 (7111003) 经费40万元 主持2011.01 — 2015.08 科技部973项目 局部脑损害(脑卒中与脑胶质瘤)的脑网络研究（2011CB707804） 经费420万元 主持 2012.01 — 2015.12 国家十二五科技支撑计划 缺血性脑血管病脑血运重建微创技术体系研究(2011BAI08B04) 经费580万元 主持 成果与专利—科技成果：1.国家科技进步二等奖(NO：2006-J-233-2-08-R05)：脊髓血管畸形的基础与临床研究 2.北京市科学技术进步奖三等奖（NO：2005医－3－013－05）：颈动脉狭窄的血管内支架治疗 3.中华医学科技进步三等奖（NO：200803003P0803）缺血性脑血管病的综合外科治疗体系的研究 4.北京市科学技术进步二等奖（NO:：2009医-5-013-03）缺血性脑血管病外科治疗研究 5.中华医学科学技术进步三等奖（NO：201003060P0702）低氧脑保护的基础研究与应用前景 6.教育部科学技术进步二等奖（NO：2011-246） 穴位与经穴脏腑相关的现代研究 排名第二—技术专利：1.　血管内点式温度传感装置 ZL200420009690.9 实用新型专利2.　半导体致冷血管内亚低温脑保护治疗仪 ZL200420009691.3 实用新型专利3.　心脑血管保健治疗仪 ZL 200710176701 实用新型专利4.　基于神经介入微导管技术的脑保护灌注液及其制备方法 ZL 200810223983 发明专利5.　低氧饱和度机体保护训练仪 ZL200820123637.X 实用新型专利6.　血栓破碎取栓器 CN102743207A 发明专利7.　血脑屏障穿透性促红细胞生成素及其应用CN101671388 发明专利奖励荣誉1.2020年，国家科技进步奖二等奖，低氧与缺血适应防治缺血性脑卒中新技术体系的创研及推广应用，第一完成人2.2019年，中华医学科技奖一等奖，缺血性脑卒中非药物防治新技术的创研与应用，第一完成人3.2017年，教育部科技进步奖一等奖，上肢远隔缺血适应新技术的建立及其防治缺血性脑卒中的临床应用，第一完成人4.2019年，北京市科技进步奖二等奖，基于血流再通的缺血性卒中脑保护救治关键技术研发及应用推广，第一完成人5.2020年，吴阶平医药创新奖，获得者6.2021年，何梁何利基金科技进步奖，获得者SCI收录文章: 1. Li G, Zeng X, Hussain M, Meng R, Liu Y, Yuan K, Sikharam C, Ding Y, Ling F, Ji X. Safety and Validity of Mechanical Thrombectomy and Thrombolysis on Severe Cerebral Venous Sinus Thrombosis. Neurosurgery. 2013 Jan 10 [Epub ahead of print] ◎2. Qi Z, Liu W, Luo Y, Ji X, Liu KJ. Normobaric hyperoxia-based neuroprotective therapies in ischemic stroke. Med Gas Res. 2013 Jan 9;3(1):2-93. Shi J, Liu Y, Duan Y, Sun Z, Wang B, Meng R, Ji X. A new idea about reducing reperfusion injury in ischemic stroke: Gradual reperfusion. Med Hypotheses. 2013 Feb;80(2):134-6.4. Liu H, Xia P, Liu M, Ji XM, Sun HB, Tao L, Mu QW. PON gene polymorphisms and ischaemic stroke: a systematic review and meta analysis. Int J Stroke. 2013 Feb;8(2):111-23.5.Chen J, Fredrickson V, Ding Y, Cheng H, Wang N, Ling F, Ji X: Enhanced neuroprotection by local intra-arterial infusion of human albumin solution and local hypothermia. Stroke 2013;44:260-262. ◎6.Guo S, Zhou Y, Xing C, Lok J, Som AT, Ning M, Ji X, Lo EH. The vasculome of the mouse brain. PLoS One. 2012;7(12)7.Fang XH, Wang WH, Zhang XQ, Liu HJ, Zhang HM, Qin XM, Wang ZC, Ji XM, Li LM: Incidence and survival of symptomatic lacunar infarction in a Beijing population: a 6-year prospective study. Eur J Neurol 2012;19:1114-1120.8.Han C, Wang Y, Jia J, Ji X, Fredrickson V, Ding Y, Sun W, Xu J, Sun YX: Bickerstaff's brainstem encephalitis, Miller Fisher syndrome and Guillain-Barre syndrome overlap in an asthma patient with negative anti-ganglioside antibodies. BMC Res Notes 2012;5:295.9.Jia LY, Hua Y, Ji XM, Liu JT: Correlation analysis of internal jugular vein abnormalities and cerebral venous sinus thrombosis. Chin Med J (Engl ) 2012;125:3671-3674.10.Li G, Zeng X, Ji T, Fredrickson V, Wang T, Hussain M, Ren C, Chen J, Sikhram C, Ding Y, Ji X: A New Thrombosis Model of the Superior Sagittal Sinus Involving Cortical Veins. World Neurosurg 2012.11.Liu XR, Luo M, Yan F, Zhang CC, Li SJ, Zhao HP, Ji XM, Luo YM: Ischemic postconditioning diminishes matrix metalloproteinase 9 expression and attenuates loss of the extracellular matrix proteins in rats following middle cerebral artery occlusion and reperfusion. CNS Neurosci Ther 2012;18:855-863.12.Zeng X, Asmaro K, Ren C, Gao M, Peng C, Ding JY, Fredrickson V, Ji X, Ding Y: Acute ethanol treatment reduces blood-brain barrier dysfunction following ischemia/reperfusion injury. Brain Res 2012;1437:127-133.13.Meng R, Asmaro K, Meng L, Liu Y, Ma C, Xi C, Li G, Ren C, Luo Y, Ling F, Jia J, Hua Y, Wang X, Ding Y, Lo EH, Ji X: Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology 2012;79: 1853-1861. ◎14.Meng R, Yan W, Wang X, Dornbos D, III, Liu Y, Ning M, Ferdinando SB, Ding Y, Ji X: CVST, distinguished from nonthrombotic CVSS before treatment - a MUST. Int J Stroke 2012;7:274.15.Meng R, Konakondla S, Wang X, Lo EH, Ding Y, Ji X: Plasma biomarker may help to distinguish acute CVST from non-thrombotic CVSS in emergency. Int J Stroke 2012;7:183-184.16. Meng R, Ji X, Dornbos D, III, Feeney K, Ding Y, Wang X: A case of Susac's syndrome in a Chinese male. J Neurol Sci 2012;314:181-182.17. Meng R, Dornbos D, III, Meng L, Wu Y, Liu Y, Li G, Li G, Li S, Sun F, Wang X, Ding Y, Ji X: Clinical differences between acute CVST and non-thrombotic CVSS. Clin Neurol Neurosurg 2012;114:1257-1262.18.Murata Y, Fujiwara N, Seo JH, Yan F, Liu X, Terasaki Y, Luo Y, Arai K, Ji X, Lo EH: Delayed inhibition of c-Jun N-terminal kinase worsens outcomes after focal cerebral ischemia. J Neurosci 2012;32:8112-8115.19. Qi ZF, Luo YM, Liu XR, Wang RL, Zhao HP, Yan F, Song ZJ, Luo M, Ji XM: AKT/GSK3beta-Dependent Autophagy Contributes to the Neuroprotection of Limb Remote Ischemic Postconditioning in the Transient Cerebral Ischemic Rat Model. CNS Neurosci Ther 2012;965-973. ◎20.Shi J, Liu Y, Duan Y, Sun Z, Wang B, Meng R, Ji X: A new idea about reducing reperfusion injury in ischemic stroke: Gradual reperfusion. Med Hypotheses 2013;80:134-136.21.Gan Y, Ji X, Hu X, Luo Y, Zhang L, Li P, Liu X, Yan F, Vosler P, Gao Y, Stetler RA, Chen J: Transgenic overexpression of peroxiredoxin-2 attenuates ischemic neuronal injury via suppression of a redox-sensitive pro-death signaling pathway. Antioxid Redox Signal 2012;17:719-732. ◎22.Gan Y, Xing J, Jing Z, Stetler RA, Zhang F, Luo Y, Ji X, Gao Y, Cao G: Mutant erythropoietin without erythropoietic activity is neuroprotective against ischemic brain injury. Stroke 2012;43:3071-3077.23.Geng X, Ren C, Wang T, Fu P, Luo Y, Liu X, Yan F, Ling F, Jia J, Du H, Ji X,Ding Y: Effect of remote ischemic postconditioning on an intracerebral hemorrhage stroke model in rats. Neurol Res 2012;34:143-148.24. Wang F, Wang Y, Geng X, Asmaro K, Peng C, Sullivan JM, Ding JY, Ji X, Ding Y: Neuroprotective effect of acute ethanol administration in a rat with transient cerebral ischemia. Stroke 2012;43:205-210. ◎25 . Wang C, Liu Y, Yang Q, Dai X, Wu S, Wang W, Ji X, Li L, Fang X: Body mass index and risk of total and type-specific stroke in Chinese adults: results from a longitudinal study in China. Int J Stroke 2012.26.Dang S, Liu X, Fu P, Gong W, Yan F, Han P, Ding Y, Ji X, Luo Y: Neuroprotection by local intra-arterial infusion of erythropoietin after focal cerebral ischemia in rats. Neurol Res 2011;33:520-528.27 .Fang XH, Wang CX, Mei LP, Liu M, Ji XM, Li LM: [Progress in epidemiology study on stroke. Zhonghua Liu Xing Bing Xue Za Zhi 2011;32:847-853.28. Fujiwara N, Mandeville ET, Geng X, Luo Y, Arai K, Wang X, Ji X, Singhal AB, Lo EH: Effect of normobaric oxygen therapy in a rat model of intracerebral hemorrhage. Stroke 2011;42:1469-1472.29 .Liu X, Wang L, Zhao S, Ji X, Luo Y, Ling F: beta-Catenin overexpression in malignant glioma and its role in proliferation and apoptosis in glioblastma cells. Med Oncol 2011;28:608-614.30.Lu J, Zhang M, Cao Y, Ma Q, Chen J, Ji X, Li K: Three-dimensional whole-brain perfused blood volume imaging with multimodal CT for evaluation of acute ischaemic stroke. Clin Radiol 2011;66:517-525.31.Ren C, Gao M, Dornbos D, III, Ding Y, Zeng X, Luo Y, Ji X: Remote ischemic post-conditioning reduced brain damage in experimental ischemia/reperfusion injury. Neurol Res 2011;33:514-519.32.Meng R, Li ZY, Ji X, Ding Y, Meng S, Wang X: Antithrombin III associated with fibrinogen predicts the risk of cerebral ischemic stroke. Clin Neurol Neurosurg 2011;113:380-386.33 . Meng R, Ji X: Plasma biomarker and stroke. Cerebrovasc Dis 2011;32:406.34.Cheng F, Xie S, Guo M, Fang H, Li X, Yin J, Lu G, Li Y, Ji X, Yu S: Alteredglucose metabolism and preserved energy charge and neuronal structures in the brain of mouse intermittently exposed to hypoxia. J Chem Neuroanat 2011;42:65-71.35.Wang Y, Cui L, Ji X, Dong Q, Zeng J, Wang Y, Zhou Y, Zhao X, Wang C, Liu L, Nguyen-Huynh MN, Claiborne JS, Wong L, Li H: The China National Stroke Registry for patients with acute cerebrovascular events: design, rationale, and baseline patient characteristics. Int J Stroke 2011;6:355-361.36.Liebelt B, Papapetrou P, Ali A, Guo M, Ji X, Peng C, Rogers R, Curry A, Jimenez D, Ding Y: Exercise preconditioning reduces neuronal apoptosis in stroke by up-regulating heat shock protein-70 (heat shock protein-72) and extracellular-signal-regulated-kinase 1/2. Neuroscience 2010;166:1091-1100.37.Zhang YZ, Zhang QH, Ye H, Zhang Y, Luo YM, Ji XM, Su YY: Distribution of lysine-specific demethylase 1 in the brain of rat and its response in transient global cerebral ischemia. Neurosci Res 2010;68:66-72.38.Gan X, Luo Y, Ling F, Ji X, Chen J, Ding Y: Outcome in acute stroke with different intra-arterial infusion rate of urokinase on thrombolysis. Interv Neuroradiol 2010;16:290-296.39.Ge P, Ji X, Ding Y, Wang X, Fu S, Meng F, Jin X, Ling F, Luo Y: Celastrol causes apoptosis and cell cycle arrest in rat glioma cells. Neurol Res 2010;32:94-100.40.Wang F, Luo Y, Ling F, Wu H, Chen J, Yan F, He Z, Goel G, Ji X, Ding Y: Comparison of neuroprotective effects in ischemic rats with different hypothermia procedures. Neurol Res 2010;32:378-383.41. Wang W, Xu J, Li L, Wang P, Ji X, Ai H, Zhang L, Li L: Neuroprotective effect of morroniside on focal cerebral ischemia in rats. Brain Res Bull 2010;83:196-201.42.Ji X, Li K, Li W, Li S, Yan F, Gong W, Luo Y: The effects of blood pressure and urokinase on brain injuries after experimental cerebral infarction in rats. Neurol Res 2009;31:204-208.43. Li L, Gao X, Zhao J, Ji X, Wei H, Luo Y: Plasma and cerebrospinal fluid substance P in post-stroke patients with depression. Psychiatry Clin Neurosci 2009;63:298-304.44.Zhang F, Wang S, Luo Y, Ji X, Nemoto EM, Chen J: When hypothermia meets hypotension and hyperglycemia: the diverse effects of adenosine 5'-monophosphate on cerebral ischemia in rats. J Cereb Blood Flow Metab 2009;29:1022-1034.45.Zhao WH, Ji XM, Ling F, Ding YC, Xing CH, Wu H, Guo M, Xuan Y, Guan B, Jiang LL: Local mild hypothermia induced by intra-arterial cold saline infusion prolongs the time window of onset of reperfusion injury after transient focal ischemia in rats. Neurol Res 2009;31:43-51.46.Meng R, Ji X, Li B, Zhou J, Li W, Ding Y: Dynamical levels of plasma F(1+2) and D-dimer in patients with acute cerebral infarction during intravenous urokinase thrombolysis. Neurol Res 2009;31:367-370.47.Miao ZR, Feng L, Li S, Zhu F, Ji X, Jiao L, Ling F: Treatment of symptomatic middle cerebral artery stenosis with balloon-mounted stents: long-term follow-up at a single center. Neurosurgery 2009;64:79-84.48.Chen J, Ji X, Ding Y, Luo Y, Cheng H, Ling F: Role of residual flow on the neuroprotective efficacy of human albumin in the rat with transient cerebral ischemia. Neurol Res 2009;31:396-401.49.Chen J, Ji X, Ding Y, Luo Y, Cheng H, Ling F: A novel approach to reduce hemorrhagic transformation after interventional management of acute stroke: catheter-based selective hypothermia. Med Hypotheses 2009;72:62-63.50. Cheng H, Ji X, Ding Y, Luo Y, Wang G, Sun X, Chen J, Ling F: Focal perfusion of circulating cooled blood reduces the infarction volume and improves neurological outcome in middle cerebral artery occlusion. Neurol Res 2009;31:340-345.51.Sun Y, Zheng DY, Ji XM, Weale P, Wu H, Jiang LD, Yang LZ: Diagnostic performance of magnetic resonance venography in the detection of recanalization in patients with chronic cerebral venous sinus thrombus. Chin Med J (Engl ) 2009;122:2428-2432.52.Gao L, Ji X, Song J, Liu P, Yan F, Gong W, Dang S, Luo Y: Puerarin protects against ischemic brain injury in a rat model of transient focal ischemia. Neurol Res 2009;31:402-406.53.Ge P, Luo Y, Fu S, Ji X, Ling F: Autophagy: a strategy for malignant gliomas' resistance to therapy. Med Hypotheses 2009;73:45-47.54.Wang B, Miao ZR, Li GL, Hua Y, Ji XM, Jiao LQ, Wang RZ, Ling F: Treatment of symptomatic complex posterior circulation cerebral artery stenosis with balloon-mounted stents: technique feasibility and outcome. Neuroradiology 2009;51:319-326.55.Wang Y, Liao X, Zhao X, Wang C, Liu L, Zhou Y, Wang C, Xue J, Gao P, Dong K, Ji X, Wang Y: Imaging-based thrombolysis trial in acute ischemic stroke-II (ITAIS-II). Int J Stroke 2009;4:49-53.56.Wu H, Jiang LD, Wrede KH, Ji XM, Zhao XQ, Tian X, Gao YF, Ling F: Local hypothermia and optimal temperature for stroke therapy in rats. Chin Med J (Engl ) 2009;122:1558-1563.57.Li L, Li Y, Ji X, Zhang B, Wei H, Luo Y: The effects of retinoic acid on the expression of neurogranin after experimental cerebral ischemia. Brain Res 2008;1226:234-240.58.Ji X, Luo Y, Ling F, Stetler RA, Lan J, Cao G, Chen J: Mild hypothermia diminishes oxidative DNA damage and pro-death signaling events after cerebral ischemia: a mechanism for neuroprotection. Front Biosci 2007;12:1737-1747.59.Luo Y, Ji X, Ling F, Li W, Zhang F, Cao G, Chen J: Impaired DNA repair via the base-excision repair pathway after focal ischemic brain injury: a protein phosphorylation-dependent mechanism reversed by hypothermic neuroprotection. Front Biosci 2007;12:1852-1862.60.Wang J, Ji X, Ling F, Luo Y, He X, Guo M, Li S, Miao Z, Zhu F, Xuan Y: A new model of reversible superior sagittal sinus thrombosis in rats. Brain Res 2007;1181:118-124.61.Drobyshevsky A, Robinson AM, Derrick M, Wyrwicz AM, Ji X, Englof I,Tan S: Sensory deficits and olfactory system injury detected by novel application of MEMRI in newborn rabbit after antenatal hypoxia-ischemia. 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Zhonghua Liu Xing Bing Xue Za Zhi 2004;25:23-26.学术报告1.The diagnosis and muti-modailty treatment for patients with intracranial thrombolysis. 5th Asia Pacific region interventional neuro-radiology and treatment conference, November 5-7, 2002, Hongkong 2.Local Brain Hypothermia Induced by Pre-reperfusion Infusion of Cold Saline into the Middle Cerebral Artery Supplied Territory in the Treatment of Experimental Stroke. 6th International Conference on Stroke, March 11-14, 2003, Orlando3.The Time Window and Methods of Endovascular Intervention for Cerebral Venous Sinus Thrombosis，11th Tiantan international stroke conference, June 24-26,2012, Beijing4.China Angioplasty & Stenting for Symptomatic Intracranial Severe Stenosis (CASSISS)- a prospective multi-center, randomized controlled trial (mRCT), 12th Tiantan international stroke conference, June 28-30,2012, Beijing5.Mild hypothermia enhances iASPP expression in a rat model of cerebral ischemia-reperfusion. 7th world stroke congress, October 13-16, 2010, Seoul, Korea6.Remote Ischemic Conditioning Reduces Brain Edema in Experimental Ischemia/Reperfusion Injury, International Stroke Conference, Feb 1-3, 2012, New Orleans7. Repeated Arm Ischemic Preconditioning is Safe and Effective for Prevention of Stroke Recurrence in Octogenarians with Symptomatic Intracranial Arterial Stenosis 8. Validity of Mechanical Thrombectomy and Thrombolysis on Severe Cerebral Venous Sinus Thrombosis代表性论文1.Chengbei Hou , Jing Lan, Yinan Lin, Haiqing Song, Yuan Wang, Wenbo Zhao , Sijie Li , Ran Meng, Junwei Hao , Yuchuan Ding , Marc I. Chimowitz, Marc Fisher, David C. Hess,David S. Liebeskind, Derek J. Hausenloy, Jie Huang, Zhenguang Li , Xiujie Han, Jinbo Yang, Jin Zhou, Peimin Che, Xinchen Zhu, Peilin Hu , Hongbo Pang , Wenwu Chen, HuishengChen,GuozhongLi,Dingbo Tao , Wei Yue , Zongen Gao, Xunming Ji*.Chronic remote ischemic conditioning in patients with symptomatic intracranial arterial stenosis (RICA): a multi-center, randomized, double-blind, sham-controlled, device trial.The Lancet Neurology. 2022. Just Accepted. 2.Di Wu, Jian Chen, Longfei Wu, Hangil Lee, Jingfei Shi, Mo Zhang, Yanhui Ma, Xiaoduo He, Zixin Zhu, Feng Yan, Chuanjie Wu, Yunxia Duan, Yongjuan Fu, Sijie Li, Xinglong Zhi, Xuxiang Zhang, Shengli Li, YuchuanDing,Xunming Ji*. A clinically relevant model of focal embolic cerebral ischemia by thrombus and thrombolysis in rhesus monkeys.Nature Protocol.2022 DOI: 10.1038/s41596-022-00707-5. 3.Zongping Fang#, Di Wu#, Jiao Deng#, Qianzi Yang, Xijing Zhang, Jian Chen, Shiquan Wang, Sijun Hu, Wugang Hou, Siming Ning, Yi Ding, Zhongmin Fan, Zhenhua Jiang, Junjun Kang, Yingying Liu, Jinlin Miao, Xunming Ji*, Hailong Dong*, LizeXiong*, An MD2-perturbing peptide has therapeutic effects in rodent and rhesus monkey models of stroke.Science Translational Medicine. 2021;13(597):eabb671613 4.Wenbo Zhao, Ran Meng, Chun Ma, Baojun Hou, Liqun Jiao, Fengshui Zhu, Weijuan Wu, Jingfei Shi, Yunxia Duan, RenlingZhang,Jing Zhang, Yongxin Sun, Hongqi Zhang, Feng Ling, Yuping Wang, Wuwei Feng, Yuchuan Ding, Bruce Ovbiagele, ,Xunming Ji*. Safety and Efficacy of Remote Ischemic Preconditioning in Patients With Severe Carotid Artery Stenosis Before Carotid Artery Stenting: A Proof-of-Concept, Randomized Controlled Trial. Circulation. 2017;135:1325-1335. 5.Yejie Shi, Lili Zhang, HongjianPu ,Leilei Mao, Xiaoming Hu, Xiaoyan Jiang, Na Xu, R Anne Stetler, Feng Zhang, Xiangrong Liu, Rehana K Leak, Richard F Keep, Xunming Ji*, Jun Chen*. Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury. Nature Communication.2016;7:10523. 6.Kazuhide Hayakawa *, ElgaEsposito ,Xiaohua Wang, Yasukazu Terasaki , Yi Liu, Changhong Xing, Xunming Ji *, Eng H Lo*. Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016 ;535:551-555.