杨蜀岚医生

主要以斑马鱼为模式动物研究人类重要疾病相关基因的功能。以第一/通讯（共同第一/通讯）作者发表SCI论文10多篇，其中2篇论文获得Facultyof1000推荐。 研究方向：人类疾病相关易感基因的致病机制研究 主要教育和工作经历： 2000年12月获博士学位。2001年到2011年期间，先后在新加坡分子和细胞生物学研究院（IMCB）从事博士后研究和担任研究员、资深研究员工作，主要以模式生物拟南芥、斑马鱼为研究对象，研究机体器官发育的分子机理。2011年12月，作为中山大学“百人计划”引进人才到本院工作，建立了斑马鱼疾病模式动物公共平台，开展人类疾病相关易感基因的致病机制研究。 社会兼职： 广东省精准医学应用学会疾病模型分会第一届委员会副主任委员。 中国实验动物学会水生实验动物专业委员会委员。 论著： WangJ#,GuoX,WangD,YangS*,Expressionpatternsofpcbpgenefamilymembersduringzebrafishembryogenesis.GeneExprPatterns.2020Jan31;35:119097.doi:10.1016/j.gep.2020.119097.[Epubaheadofprint] ZhangM#,WeiY,LiuY,GuanW,ZhangX,KongJ,LiH,YangS*,WangH*,MetastaticPhosphatasePRL-3inducesOvarianCancerStemCellSubpopulationthroughPhosphatase-independentDeacetylationModulations.iScience2020Jan24;23(1):100766.doi:10.1016/j.isci.2019.100766. ShiH#,LiH#,YuanR#,GuanW,ZhangX,ZhangS,ZhangW,TongF,LiL,SongZ,WangC,YangS*.,WangH*..PCBP1depletionpromotestumorigenesisthroughattenuationofp27Kip1mRNAstabilityandtranslation.JournalofExperimentalClinicalCancerResearch,2018,37：187.ePub，doi:10.1186/s13046-018-0840-1. XuL#,ZhangM,LiH,GuanW,LiuB,LiuF,WangH,LiJuan,YangS,TongX*，WangH*.SH3BGRLasanovelprognosticbiomarkerisdown-regulatedinacutemyeloidleukemia.LeukLymphoma.2018,59(4):918-930. GaoW#,ChenC#,ZhouT#,YangS,GaoB,ZhouH,LianC,WuZ,QiuX,YangX,AlattarE,LiuW,SuD,SunS,ChenY,CheungKMC,SongY,LukKKD,ChanD,ShamPC,XingC,KhorCC,LiuG,YangJ,DengY,HaoD,HuangD,LiQZ,XuC*,SuP*.RarecodingvariantsinMAPK7predisposetoadolescentidiopathicscoliosis.HumanMutation.2017,38(11):1500-1510 LiL#,ShiH#,ZhangM,GuoX,TongF,ZhangW,ZhouJ,WangH*,YangS*.Upregulationofmetastasis-associatedPRL-3initiateschordomainzebrafish.InternationalJournalofOncology,2016,48(4):1541-1552. TongF#,ZhangM,GuoX,ShiH,GuanW,WangH*andYangS*.ExpressionpatternsofSH3BGRfamilymembersinzebrafishdevelopment.DevelopmentGenesandEvolution2016,226(4):287-295. ZhangW#,ShiH#,ZhangM,LiuB,MaoS,LiL,TongF,LiuG,YangS*,WangH*.PolyCbindingprotein1repressesautophagythroughdownregulationofLC3Btopromotetumorcellapoptosisinstarvation.InternationalJournalofBiochemistryandCellBiology.2016,73:127-136. QuS#,LiuB,GuoX,ShiH,ZhouM,LiL,YangS,TongX*,WangH*.IndependentoncogenicandtherapeuticsignificanceofphosphatasePRL-3inFLT3-ITD–negativeacutemyeloidleukemiaCancer.2014,120(14):2130-2141. YangS#,AwSS,ChangQ,KorzhS,KorzhV*,andPengJ*.DepletionofBhmtelevatessonichedgehogtranscriptlevelstopromotepancreaticisletdevelopmentinzebrafish,Endocrinology,2011:152(12):4706-4717. KorzhS,WinataCL,ZhengW,YangS,YinA,InghamP,GongZ*.TheinteractionofepithelialIhhaandmesenchymalFgf10inzebrafishesophagealandswimbladderdevelopment.DevelopmentalBiology,2011,359：262–276. MaH#,ZhangS,JiL,ZhuH,YangS,FangX*,YangR*.MappingandinsilicoisolationoftheEUI1genecontrollingupperinternodeelongationinrice.PlantMolecularBiology,2006,60:87-94。 YangS#,PuahCS,XieL,JiangL,ZhangX,ChenL,YeD*.Over-expressionofTPD1altersthecellfatesinthearabidopsiscarpelandtapetumviageneticInteractionwithEMS1/EXS.PlantPhysiology,2005,139:186-191. JiangL#,YangS#,XieL,PuahCS,YangW,SundaresanV,YeD*.VANGUARD1encodesapectinmethylesterasethatenhancespollentubegrowthintheArabidopsisstyleandtransmittingtract.PlantCell,2005,17:584-596.(Facultyof1000推荐). YangS#,XieL,MaoH,PuahCS,YangW,JiangL,YeD*.2003.Tapetumdeterminant1geneisrequiredforcellspecializationintheArabidopsisanther.PlantCell,15:2792-2804.(Facultyof1000推荐).