林水宾医生

国家杰出青年、优秀青年科学基金获得者，国家重点研发计划国合重点专项首席科学家，广东省杰青，广东省珠江人才计划青年拔尖人才。美国基因和细胞治疗协会会刊MolecularTherapy杂志(CellPress，IF=12.1)副主编。从事肿瘤mRNA翻译异常调控的致病功能和机制研究，以通讯/第一作者（共同）发表Nature,NatureMetabolism,MolecularCell(3篇),NatureProtocols,NatureCommunications(2篇)，CellReports等论文20多篇,受邀为NatureReviews撰写综述。多次入选“中国高被引学者”和“全球前2%顶尖科学家”榜单。 研究方向： 1）mRNA翻译异常对肿瘤和干细胞的调控功能和机制研究；2）新型翻译调控因子鉴定和功能研究；3）mRNA翻译异常相关疾病的诊疗干预转化医学研究。 主要教育和工作经历： 2000-2004学士福建省厦门大学生命科学学院，国家生物科学人才培养基地班 2004-2007硕士福建省厦门大学生命科学学院，生物医学科学系 2007-2012博士美国佛罗里达大学医学院（CollegeofMedicine,UniversityofFlorida,USA） 2012-2017博士后美国哈佛大学医学院，波士顿儿童医院(HarvardMedicalSchool,BostonChildren'sHospital) 2017-至今中山大学附属第一医院转化医学研究中心工作 论著： LinS#,KuangM#.RNAmodification-mediatedmRNAtranslationregulationinlivercancer:mechanismsandclinicalperspectives.NatureReviewsGastroenterologyHepatology.2024Apr;21(4):267-281.doi:10.1038/s41575-023-00884-y.WeiW*,ZhangS*,HanH*,WangX,ZhengS,WangZ,YangC,WangL,MaJ,GuoS,WangJ,LiuL,ChoeJ,LinS.NAT10-mediatedac4CtRNAmodificationpromotesEGFRmRNAtranslationandgefitinibresistanceincancer.CellReports.2023Jul25;42(7):112810.WangZ*,YuP*,ZouY*,MaJ,HanH,WeiW,YangC,ZhengS,GuoS,WangJ,LiuL,LinS.METTL1/WDR4-mediatedtRNAm7GmodificationandmRNAtranslationcontrolpromoteoncogenesisanddoxorubicinresistance.Oncogene.2023Jun;42(23):1900-1912.LiuH*,ZengX*,RenX*,ZhangY*,HuangM*,TanL,DaiZ,LaiJ,XieW,ChenZ,PengS,XuL,ChenS,ShenS#,KuangM#,LinS#.Targetingtumor-intrinsicN7-methylguanosinetRNAmodificationinhibitsMDSCrecruitmentandimprovesanti-PD-1efficacy.Gut.2023Aug;72(8):1555-1567.PengH*,ChenB*,WeiW*,GuoS*,HanH,YangC,MaJ,WangL,PengS#,KuangM#,LinS#.N6-methyladenosine(m6A)in18SrRNApromotesfattyacidmetabolismandoncogenictransformation.NatureMetabolism.2022Aug;4(8):1041-1054.HanH*,ZhengS*,LinS.N7-methylguanosine(m7G)tRNAmodification:anovelautophagymodulatorincancer.Autophagy.2022May23:1-3.HanH*,YangC*,MaJ*,ZhangS*,ZhengS*,LingR,SunK,GuoS,HuangB,LiangY,WangL,ChenS,WangZ,WeiW,HuangY,PengH,JiangYZ,ChoeJ,LinS.N7-methylguanosinetRNAmodificationpromotesesophagealsquamouscellcarcinomatumorigenesisviatheRPTOR/ULK1/autophagyaxis.NatureCommunications.2022Mar18;13(1):1478.SuT,ChengF,QiJ,ZhangY,ZhouS,MeiL,FuS,ZhangF,LinS#,ZhuG#.ResponsiveMultivesicularPolymericNanovaccinesthatCodeliverSTINGAgonistsandNeoantigensforCombinationTumorImmunotherapy.AdvancedScience.2022Jun16;e2201895.YangC,HanH,LinS.RNAepitranscriptomics:Apromisingnewavenueforcancertherapy.MolecularTherapy.2022Jan5;30(1):2-3.ChenZ*,ZhuW*,ZhuS*,SunK,LiaoJ,LiuH,DaiZ,HanH,RenX,YangQ,ZhengS,PengB,PengS,KuangM#,LinS#.METTL1promoteshepatocarcinogenesisviam7GtRNAmodification-dependenttranslationcontrol.ClinicalandTranslationalMedicine.2021Dec;11(12):e661.DaiZ*,LiuH*,LiaoJ*,HuangC*,RenX*,ZhuW,ZhuS,PengB,LiS,LaiJ,LiangL,XuL,PengS,LinS#,KuangM#.N7-methylguanosinetRNAmodificationenhancesoncogenicmRNAtranslationandpromotesintrahepaticcholangiocarcinomaprogression.MolecularCell.2021Aug19;81(16):3339-3355.MaJ*,HanH*,HuangY*,YangC,ZhengS,CaiT,BiJ,HuangX,LiuR,HuangL,LuoY#,LiW#,LinS#.METTL1/WDR4mediatedN7-methylguanosine(m7G)tRNAmodificationsandm7GcodonusagepromotemRNAtranslationandlungcancerprogression.MolecularTherapy.2021Aug8:S1525-0016(21)00399-3.HanH*,YangC*,ZhangS*,ChengM*,GuoS,ZhuY,MaY,LiangY,WangL,ZhengS,WangZ,ChenD#,JiangYZ#,LinS#.METTL3mediatedm6AmRNAmodificationpromotesesophagealcancerinitiationandprogressionviaNotchsignalingpathway.MolecularTherapy-NucleicAcids.2021Jul21;26:333-346.LinS#,LiuQ,JiangYZ,GregoryRI#.Nucleotideresolutionprofilingofm7GtRNAmodificationbyTRAC-Seq.NatureProtocols.2019Nov;14:3220–3242.WuY*,XieL*,WangM,XiongQ,GuoY,LiangY,LiJ,ShengR,DengP,WangY,ZhengR,JiangY,YeL,ChenQ,ZhouX#,LinS#,QuanY#.Mettl3-mediatedm6ARNAmethylationregulatesthefateofbonemarrowmesenchymalstemcellsandosteoporosis.NatureCommunications2018.9:4772.ChoeJ*,LinS*,ZhangW,LiuQ,WangL,Ramirez-MoyaJ,DuP,KimW,TangS,SlizP,SantistebanP,GeorgeRE,RichardsWG,WongKK,LockerN,SlackFJ,GregoryRI.mRNAcircularizationbyMETTL3-eIF3henhancestranslationandpromotesoncogenesis.Nature2018Sep;561(7724):556-560LinS*,LiuQ*,LelyveldVS,ChoeJ,SzostakJW,GregoryRI.TheMettl1/Wdr4mediatedm7GtRNAmethylomeisrequiredfornormalmRNAtranslationandembryonicstemcellself-renewalanddifferentiation.MolecularCell.2018Jul19;71(2):244-255.LinS*,ChoeJ*,DuP,TribouletR,GregoryRI.Them6AMethyltransferaseMETTL3PromotesTranslationinHumanCancerCells.MolecularCell.2016May5;62(3):335-345.HighlightedinMolCell.2016May5;62(3):323-324andCancerDiscov.2016Jun;6(6):572.LinS,GregoryRI.MicroRNAbiogenesisincancers.NatureReviewsCancer.2015Jun;15(6):321-33.LinS,GregoryRI.Methyl-transferasesmodulateRNAsstabilityinembryonicstemcells.NatureCellBiology.2014Feb;16(2):129-31.SuT*,ZhangY*,ValerieK,WangXY,LinS#,ZhuG#.STINGactivationincancerimmunotherapy.Theranostics.2019Oct15;9(25):7759-7771.LinS,GregoryRI.IdentificationofsmallmoleculeinhibitorsofZcchc11TUTaseactivity.RNABiology.2015;12(8):792-800.LinS*,TianL*,ShenH*,et.al.DDX5isapositiveregulatorofoncogenicNOTCH1signalinginTcellacutelymphoblasticleukemia.Oncogene.2013Oct;32(40):4845-53.LinS,ShenH,JinB,et.al.BlockadeofNotchSignalinginMuscleStemCellsCausesMuscularDystrophicPhenotypeandImpairedMuscleRegeneration.StemCells.2013Apr;31(4):823-8.LinS,ShenH,LiJL,et.al.ProteomicandfunctionalanalysesrevealthechromatinreaderSFMBT1'sroleinregulatingepigeneticsilencingandthemyogenicgeneprogram.JournalofBiologicalChemistry.2013Mar1;288(9):6238-47. 其他主要工作成绩： 2013DamonRunyon-SohnPediatricFellowshipAward,DamonRunyonCancerResearchFoundation 2017YoungInvestigatoraward,Alex'sLemonadeStandFoundation