
邵兰转化医学研究中心
临床免疫学及肿瘤免疫
长期从事慢性免疫病研究,在艾默里大学和斯坦福大学工作期间,发现了自身免疫病病人免疫细胞中ATM蛋白主导的DNA损伤修复通路的缺陷可导致免疫细胞修复功能的缺失,免疫系统长期处于增殖压力下,最终导致免疫衰老和自身免疫识别的异常。此发现从一定程度改变了传统上人们对自身免疫病的认识。在美国耶鲁大学医学院工作期间,深入研究了表观遗传修饰酶--SUMO特异性蛋白酶(SENP1),并首次证明了NEMO的SUMO化特异性增强胰岛脂肪细胞炎性细胞介素的分泌,进而导致自发性糖尿病,从而首次揭示SENP1作为敏感基因在糖尿病发病中的作用。相关结果分别发表在<em>J.ExpMed.,NatureCommunication,NatureReviewRheumatology,PNAS,EMBOMM,</em><em>JournalofAutoimmunity.Arthritisrheumatism.,FrontiersinImmunology</em>等国际著名的医学杂志。并被美国临床免疫学会(FOCIS),美国免疫学会(AAI),美国类风湿学会(ACR)邀请作大会报告。此外还拥有斯坦福大学技术许可证明1项,美国专利1项及国内专利2项。
研究方向:临床免疫学及肿瘤免疫
主要教育和工作经历:
沈阳药科大学药学学士
沈阳药科大学药理硕士
中科院研究生院细胞生物学博士
2002.8-2007.3中科院动物所助理研究员
2006.4-2009.12艾默里大学(Emory)博士后
2009.12-2011.6斯坦福大学(Stanford)博士后
2011.4-2012.4斯坦福大学(Stanford)研究助理
2012.8-2016.3耶鲁大学(Yale)副研究员
2016.4-至今中山大学研究员
社会兼职:
论著:
1QiaoSu#,junJing#,WuguoLi,JiandaMa,Xuelingzhang,ZongrenWang,ZhongyangZhou,LieDai*,LanShao*,ImpairedTip60-mediatedFoxp3acetylationattenuatesregulatoryTcelldevelopmentinrheumatoidarthritis,JournalofAutoimmunity,2019,100,27-29.(IF:7.54)
2Jian‐DaMa,JunJing,Jun‐WeiWang,Ying-QianMo,Qian‐HuaLi,Jian‐ZiLin,Le‐FengShaoL*#,PierreMiossec,LieDai#.ActivationofthePGC‐1β/NFATc‐1PathwayinCirculatingOsteoclastPrecursorsAssociatedwithBoneDestructioninRheumatoidArthritis.Arthritisrheumatism.2019Aug;71(8):1252-1264.(IF:9.02)
3ShaoL*DNAdamageresponsesignalstransducestressfromrheumatoidarthritisriskfactorsintoTcelldysfunction.Frontiersinimmunology.Frontiersinimmunology.2018,December,Vol:9:3055
4张雪玲,李武国,周仲洋,郑漫妮,邵兰*.T细胞代谢异常对类风湿关节炎发生发展影响。中华风湿病学杂志.2018,22(11),114-116.1
5ShaoL,FengBY,ZhouHJ,JiWD,WangMin*Theroleofadiposederivedinflammatorycytokinesintype1diabetes(2016).Adipocyte17Mar2016:1-5.(IF:3.55)
6邵兰,冯博雅,张钰莹,周焕娇,纪卫东,王敏(2016).脂肪组织与Ⅰ型糖尿病。千人生物2016,3(1),1-6。
7ShaoL,ZhouHJ,ZhangHF,WangMin(2015).SENP1-mediatedNEMOdeSUMOyationintheadipocytelimitsinflammatoryresponsesandtype1diabetesprogression.Nat.Commun.2015,Nov24.(IF:12.12)
8ShaoL,GoronzyJJ,WeyandCM(2010).InhibitionoftheDNArepairenzymeDNA-PKcsrestoresTcellsurvivalinrheumatoidarthritis.EMBOMolecularMedicine.20102(10):415-27.(IF:11.549)
9GoronzyJJ,ShaoL,WeyandCM(2010).NewinsightsintoRheumatoidArthritis.RheumaticDiseaseClinicsofNorthAmerica.201036(2).297-310.(IF:3.34)
10ShaoL,FujiiH,GoronzyJJ,WeyandCM(2009).DeficiencyoftheDNArepairenzymeATMinRheumatoidArthritis.J.Exp.Med.2009Jun;8;206(6):1435-49.(IF:11.9)
11WeyandCM,FujiiH,ShaoL,GoronzyJJ(2009).Rejuvenatingtheimmunesysteminrheumatoidarthritis.NatRevRheumatol.20095,583-588.(IF:18.68)
12FujiiH,ShaoL,GoronzyJJ,WeyandCM(2009).Telomeraseinsufficiencyinrheumatoidarthritis.ProcNatlAcadSciUSA.2009Mar17;106(11):4360-5.(IF:9.81)
13ShaoL,LiQH,WangJ,TanZ(2005).FragmentationandrapidshorteningoftelomereinHeLacellsintheearlyphaseofhydroxylradical-inducedapoptosis.CancerBiolTher.2005;4(3):336-41.(IF:3.63)
14ShaoL,LiQH,TanZ(2004).L-carnosinereducestelomeredamageandshorteningrateinculturednormalfibroblasts.BiochemBiophysResCommun.2004,324(2):931-936.(IF:2.4)
15YangF,YangJP,LiQH,ShaoL(2003).StrandbreaksintelomeresinHelacells.ActaZoologySinica.2003,49(6):873-877.
16ShaoL,HuangQ,LiQH(2003).Regulationeffectofinsulinonmetabolicdysfunctionofdiabeticrats.ChineseJournalofZoology.2003,38(2):23-27.
17ShaoL,LiQH,HuangQ(2002).Effectofinsulinonoxidativedamageinliverofdiabeticrats.ChineseJournalofZoology.2002,37(5):28-31.
18JiaoXM,LiQH,XuM,LiLJ,ShaoL(2002).FusionofEhrlich′sascitescellplasmamembranewithliposomesdrivenbytransmembraneprontonefflux:effectofcalciumionsandliposomephospholipidcomposition.ActaZoologicaSinica.2002,48(5):660-666.
19HuangQ,ShaoL,JiangH(2001).Effectofinsulinonoxygenfreeradicalsandoxidativephosphorylationinlivermitochondrialofdiabeticrats.Acta.Pharmacol.Sina.2001,22(5):455-458.(IF:2.496)
20ShaoL,YuQH,HuangQ(2001).TheeffectofHouttuyninumoncellularimmunologicalfunctioninsplenectomyanimals.ChinesePharmacologicalBullitin.2001,17(1):51-54.
21ShaoL,YuQH(2000).TheeffectofHouttuyninumonimmunologicalfunctioninmicetreatedwithcyclophosphamide.JournalofShenyangPharmacoeuticelUniversity.2000,17(2):133-135.
22ShaoL,YuQH(1999).TheeffectofHouttuyninumonimmunologicalfunctioninsplenectomyanimals.JournalofShenyangPharmacoeuticelUniversity.1999,16(3):209-211.
23ShaoL,YuQH(1998).TheImprovingEffectofDecoctionofCoptisandItsExtractonIntelligence.JournalofShenyangPharmacoeuticelUniversity.1998,15(1):35~37.
24YeFG,YuQH,ShaoL(1998).AntioxidantActivityofCalculusBorisforLipid.ChinaJournalofTraditionalChineseMedicineandPharmacy.1998,13(2):69.
25YuQH,ZhangYF,ShaoL(1997).TheroleofImmuneregulationofChineseMedicine.MedicalJournalofLiaoning.1997,11(6):299-301.
专利
1WeyandCM,GoronzyJJ,ShaoL.ImprovingImmuneSystemFunctioninconditionscharacterizedbyelevateddoublestrandbreaks(U.S.PatentApplicationSerialNo.13/205,001,issueddata12/6/2016).
2ZhaoY,XieW,ShaoL.AtetramercombinedwithSARSAntigenPeptide,itspreparationanduse(No.200310113727).
其他主要工作成绩:
中山大学附属第一医院2015高影响因子奖
美国免疫学年会大会奖(AAI2010)
美国临床免疫学年会大会奖(FOCIS2009)