韩安家医生

医疗专长： 韩安家，中山大学附属第一医院病理科/中山医学院病理学教研室副主任。教授、主任医师。擅长软组织肿瘤和呼吸系统疾病的病理诊断，主要从事结直肠癌和软组织肿瘤发病机制研究。现任中华医学会病理学分会第十届委员会青年委员会副主任委员，广东省临床病理质量控制中心副主任兼秘书，广东省医学会病理学分会常委兼秘书，广东省医学会病理学分会软组织和骨肿瘤病理协作组组长。中华医学会病理学分会软组织和骨肿瘤病理学组（筹）委员。国家自然科学基金、中国博士后科学基金、广东省自然科学基金、北京市自然科学基金等项目评审专家。2004-2007年在UniversityofPittsburgh,MontefioreMedicalCenter,UniversityofIllinoisatChicago作访问学者。2012年在UniversityofTexasSouthwesternMedicalCenter进行临床观摩学习。主持国家自然科学基金、广东省自然科学基金等多项。近5年来在<em>JPATHOL，JNCI，EURJCANCER，INTJCANCER，CARCINOGENESIS，MOLCARCINOGEN，PLOSONE</em>等发表论著40余篇。 主编《软组织肿瘤病理学诊断图谱》（科学出版社，2014）、《病理学教学彩色图谱》（科学出版社，2003年）；参编《病理学高级教程》、《病理学》（研究生用）、《病理学与病理生理学》、《病理学与病理生理学学习指南》、《外科病理学》、《疑难外科病理诊断与鉴别诊断》、《现代肺癌病理与临床》等多部。 担任INTJCANCER,JMEDVIROL,JTumor，《中华病理学》，《临床与实验病理学杂志》，《中华肿瘤防治杂志》等编委和特邀审稿专家。获《中华病理学杂志》50周年金笔奖。 代表作(*通讯作者): ZhenT,DaiS,LiH,YangY,KangL,ShiH,ZhangF,LiangY,HanA*.MACC1promotescarcinogenesisofcolorectalcancerviaβ-cateninsignaling.Oncotarget.2014(advanceonlinepublications)（IF6.636）LiH,DaiS,ZhenT,ShiH,ZhangF,YangY,KangL,LiangY,HanA*.ClinicalandbiologicalsignificanceofmiR-378a-3pandmiR-378a-5pincolorectalcancer.EurJcancer2014,50(6):1207-1221(IF5.06)CaoQ,LiuF,NiuG,XueL,HanA*.BlasticplasmacytoiddendriticcellneoplasmwithEWSR1generearrangement.JClinPathol.2014Jan;67(1):90-2.(IF2.44)YangY,LiH,ZhangF,ShiH,ZhenT,DaiS,KangL,LiangY,WangJ,HanA*.Clinicalandbiologicalsignificanceofhepatoma-derivedgrowthfactorinEwing'ssarcoma.JPathol.2013Nov;231(3):323-34.(IF7.59)HuK,LiaoD,WuW,HanAJ,ShiHJ,WangF,WangX,ZhongL,DuanT,WuY,CaoJ,TangJ,SangY,WangL,LvX,XuS,ZhangRH,DengWG,LiSP,ZengYX,KangT*..Targetingtheanaphase-promotingcomplex/cyclosome(APC/C)-bromodomaincontaining7(BRD7)pathwayforhumanosteosarcoma.Oncotarget2013Mar21.[Epubaheadofprint]（IF6.636）ZhangF,YangQ,MengF,ShiH,LiH,LiangY,HanA*.Astrocyteelevatedgene-1interactswithβ-cateninandincreasesmigrationandinvasionofcolorectalcarcinoma.MolCarcinog.2013Aug;52(8):603-10(IF4.27)MengF,LiH,ShiH,YangQ,ZhangF,YangY,KangL,ZhenT,DaiS,DongY,HanA*.MACC1down-regulationinhibitsproliferationandtumourigenicityofnasopharyngealcarcinomacellsthroughAkt/β-cateninsignalingpathway.PLoSOne.2013;8(4):e60821.(IF3.73)YangY,ZhenT,ZhangF,DaiS,KangL,LiangY,XueL,HanA*.p53andhepatoma-derivedgrowthfactorexpressionandtheirclinicopathologicalassociationwithEwingfamilytumour.JClinPathol.2014Mar;67(3):235-42(IF2.44)ChenW,ShiH,LiuY,KeZ,HanA*.Endotrachealangiomatoid'malignant'fibroushistiocytoma:EWSR1generearrangement.Pathology.2013Aug;45(5):506-8(IF2.66)YeZ,CaoQ,NiuG,LiangY,LiuY,JiangL,YuX,HanA*.p63andp53expressioninextranodalNK/Tcelllymphoma,nasaltype.JClinPathol.2013Aug;66(8):676-80.(IF2.44)TangQL,XieXB,WangJ,ChenQ,HanAJ,ZouCY,YinJQ,LiuDW,LiangY,ZhaoZQ,YongBC,ZhangRH,FengQS,DengWG,ZhuXF,ZhouBP,ZengYX,ShenJN,KangT.Glycogensynthasekinase-3β,NF-κBsignaling,andtumorigenesisofhumanosteosarcoma.JNATLCANCERI,2012May16;104(10):749-63.(IF14.34)LiuD,ShiH,KeZ,HanA*.PrimarycardiacdiffuselargeB-celllymphoma,non-germinalcentreB-celltypeinanimmunocompetentwoman.InteractCardiovascThoracSurg.2012Aug;15(2):282-4.XiaoP,ShiH,ZhangH,MengF,PengJ,KeZ,WangK,LiuY,HanA*.Epstein-Barrvirus-associatedintrahepaticcholangiocarcinomabearinganintenselymphoplasmacyticinfiltration.JClinPathol.2012Jun;65(6):570-3.(IF2.44)SongY,YangQX,ZhangF,MengF,LiH,DongY,HanA*.Suppressionofnasopharyngealcarcinomacellbytargetingβ-cateninsignalingpathway.CancerEpidemiol.2012;36(2):e116-21(IF2.23)CaiXD,ZhouYB,HuangLX,ZengQL,ZhangLJ,WangQQ,LiSL,FengJQ,HanAJ.ReducedexpressionofKrüppel-likefactor17isrelatedtotumorgrowthandpoorprognosisinlungadenocarcinoma.BiochemBiophysResCommun.2012Feb3;418(1):67-73.(IF2.41)SunS,KeZ,WangF,LiS,ChenW,HanA,WangZ,ShiH,WangLT,ChenX.Overexpressionofastrocyte-elevatedgene-1iscloselycorrelatedwithpoorprognosisinhumannon-smallcelllungcancerandmediatesitsmetastasisthroughup-regulationofmatrixmetalloproteinase-9expression.HumPathol.2012Jul;43(7):1051-60.(IF2.84)WangZ,YangS,ShiH,DuH,XueL,WangL,DongY,HanA*.Histopathologicalandimmunophenotypicfeaturesoftesticulartumouroftheadrenogenitalsyndrome.Histopathology2011;58(7):1013-8(IF2.86)YeZ,XiaoY,ShiH,KeZ,LiuY,LiangY,HanA*.SporadicBurkittlymphomainsouthernChina:12years'experienceinasingleinstitutioninGuangzhou.JClinPathol.2011Dec;64(12):1132-5.(IF2.44)ZhangF,MengF,LiH,DongY,YangW,HanA*.SuppressionofretinoidXreceptoralphaandaberrantβ-cateninexpressionsignificantlyassociateswithprogressionofcolorectalcarcinoma.EurJCancer.2011Sep;47(13):2060-7.(IF5.06)YeC,PanL,HuangY,YeR,HanA,LiS,LiX,WangS.Somaticmutationsinexon17oftheTEKgeneinvasculartumorsandvascularmalformations.JVascSurg.2011Dec;54(6):1760-1768.(IF2.88)YeC,YinH,LinY,ZhouL,YeR,LiX,HanA,WangS.AbdominalAortaAneurysmsinChildren:Single-CenterExperienceofSixPatients.AnnThoracSurg.2011Jan;93(1):201-5(IF3.45)YouS,ZhangF,MengF,LiH,LiuQ,LiangY,DongY,YangW,HanA*.EBV-encodedLMP1increasesnuclearβ-cateninaccumulationanditstranscriptionalactivityinnasopharyngealcarcinoma.TumourBiol.2011Aug;32(4):623-30.PMID:21336584(IF2.52)YeZ,ShiH,PengT,HanA*.Clinicalandpathologicalfeaturesofhighgradeprimarycardiacosteosarcoma.InteractCardiovascThoracSurg.2011Jan;12(1):94-5PMID:21098423XiaoP,LiuD,PengJ,GaoZ,DongY,WuH,HanA*.Aggressiveangiomyxomaofsphenoidalsinus.Pathology2011；43(1):79-81PMID:21240074(IF2.66)LiuD,XiaoP,GaoZ,XueL,WangL,LiuY,HanA*.Chondroblastomawithadamantinomadifferentiationofthecalcaneus.Pathology2011;43(2)：174-176PMID:21233685(IF2.66)YangJ,ZhangF,FangH,YeZ,LinS,HanA*.Clinicopathologicfeaturesofprimarylymphomainsofttissue.LeukLymphoma.2010Nov;51(11):2039-46PMID:20929318(IF2.30)FangHQ,YangJ,ZhangFF,CuiY,HanAJ*.ClinicalandPathologicalfeaturesofGastricglomustumors.WorldJGastroenterology,2010；16(36):4616-4620PMID:20857536(IF2.55)LiuQ,HanA*,YouS,YangQ,LiangY,DongY.TheassociationofgenomicvariationofEpstein–BarrvirusBamHIFfragmentwiththeproliferationofnasopharyngealcarcinoma.APMIS2010;118(9):657-64.PMID:20718717(IF2.07)LiuL,WuJ,YingZ,ChenB,HanA,LiangY,SongL,YuanJ,LiJ,LiM.Astrocyteelevatedgene-1upregulatesmatrixmetalloproteinase-9andinduceshumangliomainvasion.CancerRes.2010;70(9):3750-9PMID:20388776(IF8.65)FangW,HanA,BiX,XiongB,YangW.Tumorinhibitionbysodiumseleniteisassociatedwithactivationofc-JunNH2-terminalkinase1andsuppressionofbeta-cateninsignaling.IntJCancer.2010;127(1):32-42PMID:19904745(IF6.20)HuD,BiX,FangW,HanA,YangW.GSK3βisinvolvedinJNK2-mediatedβ-catenininhibition.PLoSOne.2009Aug13;4(8):e6640PMID:19675674(IF3.73)WangZ,YangShicong,WangLT,HanA*.Primaryextrauterineundifferentiatedendometrialsarcomawithosseousandcartilaginousdifferentiation.Pathology,2009;41(5):503-505PMID:19900096(IF2.66)HanA.,TongC.,HuD.,BiX.,YangW.Adirectprotein-proteininteractionisinvolvedinthesuppressionofβ-catenintranscriptionbyretinoidXreceptorαincolorectalcancercells.CancerBiolTher.2008;7(3)454-459PMID:181196974HanA.，SongZ,TongC,HuD,BiX,AugenlichtLH,YangW.Sulindacsuppressesβ-cateninexpressioninhumancancercells.EurJPharmacol.2008;583(1)26-31PMID:18291362HuD,FangW,HanA,GallagherL,DavisRJ,XiongB,YangW.c-JunNH2-terminalkinase1interactswithandnegativelyregulatesWnt/{beta}-cateninsignalingthroughGSK3{beta}pathway.Carcinogenesis.2008；29(12):2317-24PMID:18952597FengC,HanA,YeC,XuR,LiM.TheHMG-CoAReductasePathway,StatinsandAngioprevention.SeminOphthalmol.2006,21(1):29-35PMID:16517442HanAJ*,XiongM,GuYY,etal.Lymphoepithelioma-likecarcinomaofthelungwithabetterprognosis:Aclinicopathologicstudyof32cases.AmJClinPathol2001,115(6):841-850PMID:11392880HanAJ*,XiongM,ZongYS.AssociationofEpstein-BarrViruswithlymphoepithelioma-likecarcinomaofthelunginSouthernChina.AmJClinPathol2000,114(2):220-226PMID:10941337